Deletion of the Thyroid Hormone–Activating Type 2 Deiodinase Rescues Cone Photoreceptor Degeneration but Not Deafness in Mice Lacking Type 3 Deiodinase

Type 2 deiodinase amplifies and type 3 deiodinase depletes levels of the active form of thyroid hormone, triiodothyronine. Given the opposing activities of these enzymes, we tested the hypothesis that they counteract each other’s developmental functions by investigating whether deletion of type 2 de...

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Veröffentlicht in:Endocrinology
Hauptverfasser: Ng, Lily, Liu, Hong, St. Germain, Donald L., Hernandez, Arturo, Forrest, Douglas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2017
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460942/
https://ncbi.nlm.nih.gov/pubmed/28324012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2017-00055
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