Effects of (1E,4E)-2-Methyl-1,5-bis(4-nitrophenyl)penta-1,4-dien-3-one on Trypanosoma cruzi and Its Combinational Effect with Benznidazole, Ketoconazole, or Fluconazole

This study reports the activity induced by (1E,4E)-2-methyl-1,5-bis(4-nitrophenyl)penta-1,4-dien-3-one (A3K2A3) against Trypanosoma cruzi. This compound showed trypanocidal activity against the multiplicative epimastigote and amastigote forms of this protozoan, with IC(50) values of 1.99 ± 0.17 and...

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Bibliographische Detailangaben
Veröffentlicht in:Biomed Res Int
Hauptverfasser: Peron, Francieli, Lazarin-Bidóia, Danielle, Ud Din, Zia, Rodrigues-Filho, Edson, Ueda-Nakamura, Tânia, Silva, Sueli de Oliveira, Nakamura, Celso Vataru
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460392/
https://ncbi.nlm.nih.gov/pubmed/28620619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/7254193
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