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Multiplex gene regulation by CRISPR-ddCpf1

The clustered regularly interspaced short palindromic repeats (CRISPR)/dCas9 system has been widely applied in both transcriptional regulation and epigenetic studies. However, for multiple targets, independent expression of multiple single guide RNAs (sgRNAs) is needed, which is less convenient. To...

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Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Zhang, Xiaochun, Wang, Jingman, Cheng, Qiuxiang, Zheng, Xuan, Zhao, Guoping, Wang, Jin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460296/
https://ncbi.nlm.nih.gov/pubmed/28607761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2017.18
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