Clinical responses to ERK inhibition in BRAF(V600E)-mutant colorectal cancer predicted using a computational model

Approximately 10% of colorectal cancers harbor BRAF (V600E) mutations, which constitutively activate the MAPK signaling pathway. We sought to determine whether ERK inhibitor (GDC-0994)-containing regimens may be of clinical benefit to these patients based on data from in vitro (cell line) and in viv...

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Опубликовано в: :NPJ Syst Biol Appl
Главные авторы: Kirouac, Daniel C., Schaefer, Gabriele, Chan, Jocelyn, Merchant, Mark, Orr, Christine, Huang, Shih-Min A., Moffat, John, Liu, Lichuan, Gadkar, Kapil, Ramanujan, Saroja
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460205/
https://ncbi.nlm.nih.gov/pubmed/28649441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41540-017-0016-1
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