Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease

One third of patients with inflammatory bowel disease (IBD) inadequately respond to anti-TNF treatment and preclinical data suggest that matrix metalloproteinase-9 (MMP-9) is a novel therapeutic target. Here we show that IBD clinical and histopathological parameters found in wild type mice challenge...

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Publicat a:Nat Commun
Autors principals: de Bruyn, Magali, Breynaert, Christine, Arijs, Ingrid, De Hertogh, Gert, Geboes, Karel, Thijs, Greet, Matteoli, Gianluca, Hu, Jialiang, Van Damme, Jo, Arnold, Bernd, Ferrante, Marc, Vermeire, Séverine, Van Assche, Gert, Opdenakker, Ghislain
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460016/
https://ncbi.nlm.nih.gov/pubmed/28561062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15384
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