Evaluation of Factors Influencing Antibody Reduction for Development of Antibody Drug Conjugates

BACKGROUND: Reduction/alkylation is one of the leading strategies for the development of antibody drug conjugates (ADCs). Precise control of the reduction process would not only yield a defined number of free thiols per antibody but also result in development of more homogenous conjugates. METHODS:...

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Detalhes bibliográficos
Publicado no:Iran Biomed J
Main Authors: Abdollahpour-Alitappeh, Meghdad, Lotfinia, Majid, Razavi-Vakhshourpour, Sepand, Jahandideh, Saeed, Najminejad, Hamid, Sepehr, Koushan Sineh, Moazami, Reza, Shams, Elnaz, Habibi-Anbouhi, Mahdi, Abolhassani, Mohsen
Formato: Artigo
Idioma:Inglês
Publicado em: Pasteur Institute 2017
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459942/
https://ncbi.nlm.nih.gov/pubmed/28410549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18869/acadpub.ibj.21.4.270
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