Estradiol upregulates voltage-gated sodium channel 1.7 in trigeminal ganglion contributing to hyperalgesia of inflamed TMJ

BACKGROUND: Temporomandibular disorders (TMDs) have the highest prevalence in women of reproductive age. The role of estrogen in TMDs and especially in TMDs related pain is not fully elucidated. Voltage-gated sodium channel 1.7 (Nav1.7) plays a prominent role in pain perception and Nav1.7 in trigemi...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Bi, Rui-Yun, Meng, Zhen, Zhang, Peng, Wang, Xue-Dong, Ding, Yun, Gan, Ye-Hua
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459440/
https://ncbi.nlm.nih.gov/pubmed/28582470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178589
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