Pre-BCR Signaling In Precursor B-cell Acute Lymphoblastic Leukemia regulates PI3K/AKT, FOXO1, and MYC, and can be targeted by SYK inhibition

Pre-BCR signaling and SYK recently were introduced as therapeutic targets for patients with B-cell acute lymphoblastic leukemia (B-ALL), but the importance of this pathway in B-ALL subsets and mechanism of downstream signaling have not fully been elucidated. Here, we provide new detailed insight int...

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Publicado no:Leukemia
Main Authors: Köhrer, Stefan, Havranek, Ondrej, Seyfried, Felix, Hurtz, Christian, Coffey, Greg P., Kim, Ekaterina, Hacken, Elisa ten, Jäger, Ulrich, Vanura, Katrina, O’Brien, Susan, Thomas, Deborah A., Kantarjian, Hagop, Ghosh, Dipanjan, Wang, Zhiqiang, Zhang, Min, Ma, Wencai, Jumaa, Hassan, Debatin, Klaus-Michael, Müschen, Markus, Meyer, Lüder H., Davis, R. Eric, Burger, Jan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459356/
https://ncbi.nlm.nih.gov/pubmed/26847027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.9
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