Tumor hypoxia modulates podoplanin/CCL21 interactions in CCR7+ NK cell recruitment and CCR7+ tumor cell mobilization

Podoplanin (PDPN), an O-glycosylated, transmembrane, mucin-type glycoprotein, is expressed by cancer associated fibroblasts (CAFs). In malignant transformation, PDPN is subjected to changes and its role is yet to be established. Here we show that it is involved in modulating the activity of the CCL2...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Tejchman, Anna, Lamerant-Fayel, Nathalie, Jacquinet, Jean-Claude, Bielawska-Pohl, Aleksandra, Mleczko-Sanecka, Katarzyna, Grillon, Catherine, Chouaib, Salem, Ugorski, Maciej, Kieda, Claudine
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458255/
https://ncbi.nlm.nih.gov/pubmed/28416768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16311
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