Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy

Adoptive T-cell immunotherapy is a promising approach to cancer therapy. Stem cell memory T (T(SCM)) cells have been proposed as a class of long-lived and highly proliferative memory T cells. CD8(+) T(SCM) cells can be generated in vitro from naive CD8(+) T cells via Wnt signalling; however, methods...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Kondo, Taisuke, Morita, Rimpei, Okuzono, Yuumi, Nakatsukasa, Hiroko, Sekiya, Takashi, Chikuma, Shunsuke, Shichita, Takashi, Kanamori, Mitsuhiro, Kubo, Masato, Koga, Keiko, Miyazaki, Takahiro, Kassai, Yoshiaki, Yoshimura, Akihiko
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458121/
https://ncbi.nlm.nih.gov/pubmed/28530241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15338
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