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Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling

Effective derivation of functional airway organoids from induced pluripotent stem cells (iPSCs) would provide valuable models of lung disease and facilitate precision therapies for airway disorders such as cystic fibrosis. However, limited understanding of human airway patterning has made this goal...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: McCauley, Katherine B., Hawkins, Finn, Serra, Maria, Thomas, Dylan, Jacob, Anjali, Kotton, Darrell N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457392/
https://ncbi.nlm.nih.gov/pubmed/28366587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.03.001
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