Site-Directed Mutagenesis Analysis of Amino Acids Critical for Activity of the Type I Signal Peptidase of the Archaeon Methanococcus voltae

Site-directed mutagenesis studies of the signal peptidase of the methanogenic archaeon Methanococcus voltae identified three conserved residues (Ser(52), His(122), and Asp(148)) critical for activity. The requirement for one conserved aspartic acid residue distinguishes the archaeal enzyme from both...

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Bibliographic Details
Main Authors: Bardy, Sonia L., Ng, Sandy Y. M., Carnegie, David S., Jarrell, Ken F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Enzymes and Proteins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC545723/
https://ncbi.nlm.nih.gov/pubmed/15659694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.187.3.1188-1191.2005
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