Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis.
The early events that occur after interferon binds to discrete cell surface receptors remain largely unknown. Human leukocyte interferon (interferon-alpha) rapidly increases the binding of [3H]phorbol dibutyrate to intact HeLa cells (ED50 = 100 units/ml), a measure of protein kinase C activation, an...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1990
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54571/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2168551/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.17.6537 |
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