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Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium

Here we report a genetically modified bacteria strain, Salmonella typhimurium A1, selected for anticancer activity in vivo. The strain grows in tumor xenografts. In sharp contrast, normal tissue is cleared of these bacteria even in immunodeficient athymic mice. S. typhimurium A1 is auxotrophic (Leu/...

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Detalhes bibliográficos
Main Authors: Zhao, Ming, Yang, Meng, Li, Xiao-Ming, Jiang, Ping, Baranov, Eugene, Li, Shukuan, Xu, Mingxu, Penman, Sheldon, Hoffman, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC545558/
https://ncbi.nlm.nih.gov/pubmed/15644448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408422102
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