Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium

Here we report a genetically modified bacteria strain, Salmonella typhimurium A1, selected for anticancer activity in vivo. The strain grows in tumor xenografts. In sharp contrast, normal tissue is cleared of these bacteria even in immunodeficient athymic mice. S. typhimurium A1 is auxotrophic (Leu/...

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Bibliographische Detailangaben
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Zhao, Ming, Yang, Meng, Li, Xiao-Ming, Jiang, Ping, Baranov, Eugene, Li, Shukuan, Xu, Mingxu, Penman, Sheldon, Hoffman, Robert M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545558/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15644448/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408422102
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