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Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses

Molecular characterization of the severe acute respiratory syndrome coronavirus has revealed genetic diversity among isolates. The spike (S) glycoprotein, the major target for vaccine and immune therapy, shows up to 17 substitutions in its 1,255-aa sequence; however, the biologic significance of the...

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Detalhes bibliográficos
Main Authors: Yang, Zhi-yong, Werner, Heidi C., Kong, Wing-pui, Leung, Kwanyee, Traggiai, Elisabetta, Lanzavecchia, Antonio, Nabel, Gary J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC545557/
https://ncbi.nlm.nih.gov/pubmed/15642942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409065102
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