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Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production
The natural concentration of the anticancer drug Taxol is about 0.02% in yew trees, whereas that of its analogue 7-β-xylosyl-10-deacetyltaxol is up to 0.5%. While this compound is not an intermediate in Taxol biosynthetic route, it can be converted into Taxol by de-glycosylation and acetylation. Her...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5454391/ https://ncbi.nlm.nih.gov/pubmed/28516951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15544 |
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