Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma

A well-studied RNA-binding protein Hu Antigen-R (HuR), controls post-transcriptional gene regulation and undergoes stress-activated caspase-3 dependent cleavage in cancer cells. The cleavage products of HuR are known to promote cell death however, the underlying molecular mechanisms facilitating cas...

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Vydáno v:Oncogene
Hlavní autoři: Janakiraman, Harinarayanan, House, Reniqua P., Talwar, Sudha, Courtney, Sean M., Hazard, E. Starr, Hardiman, Gary, Mehrotra, Shikhar, Howe, Philip H, Gangaraju, Vamsi, Palanisamy, Viswanathan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453834/
https://ncbi.nlm.nih.gov/pubmed/27941877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.451
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