Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma

BACKGROUND: Allergen-specific immunotherapy (AIT) is the only curative treatment for type-1 allergies, but sometimes shows limited therapeutic response as well as local and systemic side effects. Limited control of local inflammation and patient symptoms hampers its widespread use in severe allergic...

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Veröffentlicht in:PLoS One
Hauptverfasser: Aguilar-Pimentel, Antonio, Graessel, Anke, Alessandrini, Francesca, Fuchs, Helmut, Gailus-Durner, Valerie, Hrabě de Angelis, Martin, Russkamp, Dennis, Chaker, Adam, Ollert, Markus, Blank, Simon, Gutermuth, Jan, Schmidt-Weber, Carsten B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453633/
https://ncbi.nlm.nih.gov/pubmed/28570653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178563
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