Hypothyroidism in utero stimulates pancreatic beta cell proliferation and hyperinsulinaemia in the ovine fetus during late gestation

KEY POINTS: Thyroid hormones are important regulators of growth and maturation before birth, although the extent to which their actions are mediated by insulin and the development of pancreatic beta cell mass is unknown. Hypothyroidism in fetal sheep induced by removal of the thyroid gland caused as...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Harris, Shelley E., De Blasio, Miles J., Davis, Melissa A., Kelly, Amy C., Davenport, Hailey M., Wooding, F. B. Peter, Blache, Dominique, Meredith, David, Anderson, Miranda, Fowden, Abigail L., Limesand, Sean W., Forhead, Alison J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Endocrine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451716/
https://ncbi.nlm.nih.gov/pubmed/28144955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273555
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