Targeting endogenous proteins for degradation through the affinity-directed protein missile system

Targeted proteolysis of endogenous proteins is desirable as a research toolkit and in therapeutics. CRISPR/Cas9-mediated gene knockouts are irreversible and often not feasible for many genes. Similarly, RNA interference approaches necessitate prolonged treatments, can lead to incomplete knockdowns a...

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Udgivet i:Open Biol
Main Authors: Fulcher, Luke J., Hutchinson, Luke D., Macartney, Thomas J., Turnbull, Craig, Sapkota, Gopal P.
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451546/
https://ncbi.nlm.nih.gov/pubmed/28490657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.170066
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