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Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity

Genetic variants at the solute carrier family 39 member 8 (SLC39A8) gene locus are associated with the regulation of whole-blood manganese (Mn) and multiple physiological traits. SLC39A8 encodes ZIP8, a divalent metal ion transporter best known for zinc transport. Here, we hypothesized that ZIP8 reg...

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Podrobná bibliografie
Vydáno v:J Clin Invest
Hlavní autoři: Lin, Wen, Vann, David R., Doulias, Paschalis-Thomas, Wang, Tao, Landesberg, Gavin, Li, Xueli, Ricciotti, Emanuela, Scalia, Rosario, He, Miao, Hand, Nicholas J., Rader, Daniel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451243/
https://ncbi.nlm.nih.gov/pubmed/28481222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90896
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