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Retinoic Acid–related Orphan Receptor-α Is Induced in the Setting of DNA Damage and Promotes Pulmonary Emphysema

Rationale: The discovery that retinoic acid–related orphan receptor (Rora)-α is highly expressed in lungs of patients with COPD led us to hypothesize that Rora may contribute to the pathogenesis of emphysema. Objectives: To determine the role of Rora in smoke-induced emphysema. Methods: Cigarette sm...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Am J Respir Crit Care Med
Κύριοι συγγραφείς: Shi, Ying, Cao, Jiaofei, Gao, Jane, Zheng, Liang, Goodwin, Andrew, An, Chang Hyoek, Patel, Avignat, Lee, Janet S., Duncan, Steven R., Kaminski, Naftali, Pandit, Kusum V., Rosas, Ivan O., Choi, Augustine M. K., Morse, Danielle
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Thoracic Society 2012
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5450975/
https://ncbi.nlm.nih.gov/pubmed/22744720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201111-2023OC
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