Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells

BACKGROUND: Bisdioxopiperazine anti-cancer agents are inhibitors of eukaryotic DNA topoisomerase II, sequestering this protein as a non-covalent protein clamp on DNA. It has been suggested that such complexes on DNA represents a novel form of DNA damage to cells. In this report, we characterise the...

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Autori principali: Jensen, Lars H, Dejligbjerg, Marielle, Hansen, Lasse T, Grauslund, Morten, Jensen, Peter B, Sehested, Maxwell
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2004
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC545072/
https://ncbi.nlm.nih.gov/pubmed/15575955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-4-31
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