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The undoing and redoing of the diabetic β-cell: β-cell de-differentiation in type 2 diabetes mellitus and re-differentiation and recovery with β-cell rest: Matching clinical observations with experimental insights

A hallmark of type 2 diabetes (T2DM) is the reduction in functional β-cell mass, which is considered at least in part to result from an imbalance of β-cell renewal and apoptosis, with the latter being accelerated during metabolic stress. More recent studies, however, suggest that the loss of functio...

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Bibliographische Detailangaben
Veröffentlicht in:J Diabetes Complications
Hauptverfasser: Wang, Wei, Liu, Chune, Gonzalez, Maria Jimenez, Song, Woo-Jin, Hussain, Mehboob A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5450161/
https://ncbi.nlm.nih.gov/pubmed/28242267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jdiacomp.2017.01.028
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