A Toxin Involved in Salmonella Persistence Regulates Its Activity by Acetylating Its Cognate Antitoxin, a Modification Reversed by CobB Sirtuin Deacetylase

Bacterial toxin-antitoxin systems trigger the onset of a persister state by inhibiting essential cellular processes. The TacT toxin of Salmonella enterica is known to induce a persister state in macrophages through the acetylation of aminoacyl-tRNAs. Here, we show that the TacT toxin and the TacA an...

Full description

Saved in:
Bibliographic Details
Published in:mBio
Main Authors: VanDrisse, Chelsey M., Parks, Anastacia R., Escalante-Semerena, Jorge C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449658/
https://ncbi.nlm.nih.gov/pubmed/28559487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00708-17
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items