New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival

Comparative modeling of the DNA-binding domain of human HSF1 facilitated the prediction of possible binding pockets for small molecules and definition of corresponding pharmacophores. In silico screening of a large library of lead-like compounds identified a set of compounds that satisfied the pharm...

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Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: Vilaboa, Nuria, Boré, Alba, Martin-Saavedra, Francisco, Bayford, Melanie, Winfield, Natalie, Firth-Clark, Stuart, Kirton, Stewart B., Voellmy, Richard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2017
Konular:
Gene regulation, Chromatin and Epigenetics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449623/
https://ncbi.nlm.nih.gov/pubmed/28369544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx194
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