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New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival
Comparative modeling of the DNA-binding domain of human HSF1 facilitated the prediction of possible binding pockets for small molecules and definition of corresponding pharmacophores. In silico screening of a large library of lead-like compounds identified a set of compounds that satisfied the pharm...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5449623/ https://ncbi.nlm.nih.gov/pubmed/28369544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx194 |
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