Are zinc-bound metallothionein isoforms (I+II and III) involved in impaired thymulin production and thymic involution during ageing?

BACKGROUND: With advancing age, thymic efficiency shows progressive decline due to thymic involution allowing impaired cell-mediated immunity and the appearance of age-related diseases. The intrinsic cause of thymic involution is still undefined. Chronic inflammation and high glucocorticoids (GCs) m...

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Autors principals: Mocchegiani, Eugenio, Giacconi, Robertina, Cipriano, Catia, Muti, Elisa, Gasparini, Nazzarena, Malavolta, Marco
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2004
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC544958/
https://ncbi.nlm.nih.gov/pubmed/15679929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4933-1-5
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