Inhibition of the Mitochondrial Glutamate Carrier SLC25A22 in Astrocytes Leads to Intracellular Glutamate Accumulation

The solute carrier family 25 (SLC25) drives the import of a large diversity of metabolites into mitochondria, a key cellular structure involved in many metabolic functions. Mutations of the mitochondrial glutamate carrier SLC25A22 (also named GC1) have been identified in early epileptic encephalopat...

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Pubblicato in:Front Cell Neurosci
Autori principali: Goubert, Emmanuelle, Mircheva, Yanina, Lasorsa, Francesco M., Melon, Christophe, Profilo, Emanuela, Sutera, Julie, Becq, Hélène, Palmieri, Ferdinando, Palmieri, Luigi, Aniksztejn, Laurent, Molinari, Florence
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449474/
https://ncbi.nlm.nih.gov/pubmed/28620281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2017.00149
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