Chromosomal passenger complex hydrodynamics suggests chaperoning of the inactive state by nucleoplasmin/nucleophosmin

The chromosomal passenger complex (CPC) is a conserved, essential regulator of cell division. As such, significant anti–cancer drug development efforts have been focused on targeting it, most notably by inhibiting its AURKB kinase subunit. The CPC is activated by AURKB-catalyzed autophosphorylation...

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Bibliographic Details
Published in:Mol Biol Cell
Main Authors: Hanley, Mariah L., Yoo, Tae Yeon, Sonnett, Matthew, Needleman, Daniel J., Mitchison, Timothy J.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2017
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449145/
https://ncbi.nlm.nih.gov/pubmed/28404751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-12-0860
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