Expression of human factor IX in rabbit hepatocytes by retrovirus-mediated gene transfer: potential for gene therapy of hemophilia B.

Hemophilia B (Christmas disease) is a chromosome X-linked blood clotting disorder which results when factor IX is deficient or functionally defective. The enzyme is synthesized in the liver, and the existence of animal models for this genetic disease will permit the development of somatic gene thera...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Armentano, D, Thompson, A R, Darlington, G, Woo, S L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54488/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2385589/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.16.6141
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