Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence

BACKGROUND: Defensins are important components of innate immunity to combat bacterial and viral infections, and can even elicit antitumor responses. Clusters of defensin (DEF) genes are located in a 2 Mb range of the human chromosome 8p23.1. This DEF locus, however, represents one of the regions in...

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Detalhes bibliográficos
Main Authors: Taudien, Stefan, Galgoczy, Petra, Huse, Klaus, Reichwald, Kathrin, Schilhabel, Markus, Szafranski, Karol, Shimizu, Atsushi, Asakawa, Shuichi, Frankish, Adam, Loncarevic, Ivan F, Shimizu, Nobuyoshi, Siddiqui, Roman, Platzer, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC544879/
https://ncbi.nlm.nih.gov/pubmed/15588320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-5-92
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