Hypoxia-inducible factor 1 alpha is a poor prognostic factor and potential therapeutic target in malignant peripheral nerve sheath tumor

BACKGROUND: Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma with poor prognosis. Hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the cellular response to hypoxia and regulates the expression of multiple genes involved in tumor progression in various cancers....

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Publicado en:PLoS One
Main Authors: Fukushima, Suguru, Endo, Makoto, Matsumoto, Yoshihiro, Fukushi, Jun-ichi, Matsunobu, Tomoya, Kawaguchi, Ken-ichi, Setsu, Nokitaka, IIda, Keiichiro, Yokoyama, Nobuhiko, Nakagawa, Makoto, Yahiro, Kenichiro, Oda, Yoshinao, Iwamoto, Yukihide, Nakashima, Yasuharu
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448771/
https://ncbi.nlm.nih.gov/pubmed/28558056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178064
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