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Controlling the family-wise error rate in multi-arm, multi-stage trials

BACKGROUND AND AIMS: Multi-arm, multi-stage trials have recently gained attention as a means to improve the efficiency of the clinical trials process. Many designs have been proposed, but few explicitly consider the inherent issue of multiplicity and the associated type I error rate inflation. It is...

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Detalhes bibliográficos
Publicado no:Clin Trials
Main Authors: Crouch, Luis A., Dodd, Lori E., Proschan, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448294/
https://ncbi.nlm.nih.gov/pubmed/28545335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774517694130
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