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Production of homogeneous glycoprotein with multisite modifications by an engineered N-glycosyltransferase mutant

Naturally occurring N-glycoproteins exhibit glycoform heterogeneity with respect to N-glycan sequon occupancy (macroheterogeneity) and glycan structure (microheterogeneity). However, access to well-defined glycoproteins is always important for both basic research and therapeutic purposes. As a resul...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Song, Qitao, Wu, Zhigang, Fan, Yueyuan, Song, Woran, Zhang, Peiru, Wang, Li, Wang, Faxing, Xu, Yangyang, Wang, Peng G., Cheng, Jiansong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448120/
https://ncbi.nlm.nih.gov/pubmed/28381551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.777383
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