Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a fatal progressive muscle-wasting disease. Various attempts are underway to convert severe DMD to a milder phenotype by modulating the splicing of the dystrophin gene and restoring its expression. In our previous study, we reported TG003, an inhibitor of CDC2-li...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Sako, Yukiya, Ninomiya, Kensuke, Okuno, Yukiko, Toyomoto, Masayasu, Nishida, Atsushi, Koike, Yuka, Ohe, Kenji, Kii, Isao, Yoshida, Suguru, Hashimoto, Naohiro, Hosoya, Takamitsu, Matsuo, Masafumi, Hagiwara, Masatoshi
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448077/
https://ncbi.nlm.nih.gov/pubmed/28555643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46126
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires