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Mutational and Kinetic Analysis of Lesion Recognition by Escherichia coli Endonuclease VIII

Escherichia coli endonuclease VIII (Endo VIII) is a DNA glycosylase with substrate specificity for a wide range of oxidatively damaged pyrimidine bases. Endo VIII catalyzes hydrolysis of the N-glycosidic bond and β, δ-elimination of 3′- and 5′-phosphate groups of an apurinic/apyrimidinic site. Singl...

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Detalles Bibliográficos
Publicado en:Genes (Basel)
Main Authors: Kladova, Olga A., Kuznetsova, Alexandra A., Fedorova, Olga S., Kuznetsov, Nikita A.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448014/
https://ncbi.nlm.nih.gov/pubmed/28505099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes8050140
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