Identification of Epigallocatechin-3- Gallate as an Inhibitor of Phosphoglycerate Mutase 1

Targeting metabolic enzymes is believed to provide new therapeutic opportunities for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly coordinates glycolysis, pentose phosphate pathway (PPP) flux and serine biosynthesis in cancer cells and hence gains increasi...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Li, Xiaoguang, Tang, Shuai, Wang, Qian-Qian, Leung, Elaine L.-H., Jin, Hongyue, Huang, Yongzhuo, Liu, Jia, Geng, Meiyu, Huang, Min, Yuan, Shengtao, Yao, Xiao-Jun, Ding, Jian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5447756/
https://ncbi.nlm.nih.gov/pubmed/28611670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00325
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