Mono-Heteromeric Configurations of Gap Junction Channels Formed by Connexin43 and Connexin45 Reduce Unitary Conductance and Determine both Voltage Gating and Metabolic Flux Asymmetry

In cardiac tissues, the expression of multiple connexins (Cx40, Cx43, Cx45, and Cx30.2) is a requirement for proper development and function. Gap junctions formed by these connexins have distinct permeability and gating mechanisms. Since a single cell can express more than one connexin isoform, the...

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Detalles Bibliográficos
Publicado en:Front Physiol
Main Authors: Zhong, Guoqiang, Akoum, Nazem, Appadurai, Daniel A., Hayrapetyan, Volodya, Ahmed, Osman, Martinez, Agustin D., Beyer, Eric C., Moreno, Alonso P.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017
Assuntos:
Physiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5447054/
https://ncbi.nlm.nih.gov/pubmed/28611680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00346
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