Hypoxia-inducible factor 1 α protects mesenchymal stem cells against oxygen-glucose deprivation-induced injury via autophagy induction and PI3K/AKT/mTOR signaling pathway

Mesenchymal stem cell (MSC) transplantation is a promising therapeutic strategy for myocardial infarction. The survival rate of the grafted MSCs is limited by the conditions of hypoxia and low nutrient levels. In this study, we investigated the role of hypoxia-inducible factor 1 alpha (Hif-1α) in ox...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Am J Transl Res
Main Authors: Lv, Bingke, Hua, Tian, Li, Feng, Han, Jianbang, Fang, Jie, Xu, Limin, Sun, Chengmei, Zhang, Zhongfei, Feng, Zhiming, Jiang, Xiaodan
Format: Artigo
Jezik:Inglês
Izdano: e-Century Publishing Corporation 2017
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446531/
https://ncbi.nlm.nih.gov/pubmed/28559999
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