Hyperoxia provokes a time- and dose-dependent inflammatory response in mechanically ventilated mice, irrespective of tidal volumes

BACKGROUND: Mechanical ventilation and hyperoxia have the potential to independently promote lung injury and inflammation. Our purpose was to study both time- and dose-dependent effects of supplemental oxygen in an experimental model of mechanically ventilated mice. METHODS: Healthy male C57Bl/6J mi...

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Detalhes bibliográficos
Publicado no:Intensive Care Med Exp
Main Authors: Helmerhorst, Hendrik J. F., Schouten, Laura R. A., Wagenaar, Gerry T. M., Juffermans, Nicole P., Roelofs, Joris J. T. H., Schultz, Marcus J., de Jonge, Evert, van Westerloo, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446430/
https://ncbi.nlm.nih.gov/pubmed/28550659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-017-0142-5
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