Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

Autophagy is a membrane-trafficking process that directs degradation of cytoplasmic material in lysosomes. The process promotes cellular fidelity, and while the core machinery of autophagy is known, the mechanisms that promote and sustain autophagy are less well defined. Here we report that the epig...

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Vydáno v:Mol Cell
Hlavní autoři: Sakamaki, Jun-ichi, Wilkinson, Simon, Hahn, Marcel, Tasdemir, Nilgun, O’Prey, Jim, Clark, William, Hedley, Ann, Nixon, Colin, Long, Jaclyn S., New, Maria, Van Acker, Tim, Tooze, Sharon A., Lowe, Scott W., Dikic, Ivan, Ryan, Kevin M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446411/
https://ncbi.nlm.nih.gov/pubmed/28525743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.04.027
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