Rhinovirus infection results in stronger and more persistent genomic dysregulation: Evidence for altered innate immune response in asthmatics at baseline, early in infection, and during convalescence

BACKGROUND: Rhinovirus (HRV) is associated with the large majority of virus-induced asthma exacerbations in children and young adults, but the mechanisms remain poorly defined. METHODS: Asthmatics and non-asthmatic controls were inoculated with HRV-A16, and nasal epithelial samples were obtained 7 d...

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Bibliographic Details
Published in:PLoS One
Main Authors: Heymann, Peter W., Nguyen, Huyen-Tran, Steinke, John W., Turner, Ronald B., Woodfolk, Judith A., Platts-Mills, Thomas A. E., Martin, Lisa, He, Hua, Biagini Myers, Jocelyn, Lindsey, Mark, Sivaprasad, Umasundari, Medvedovic, Mario, Mahi, Naim, Carper, Holliday, Murphy, Deborah D., Patrie, James, Khurana Hershey, Gurjit K.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446117/
https://ncbi.nlm.nih.gov/pubmed/28552993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178096
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