The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability

Central nervous system (CNS) inflammation and autophagy dysfunction are known to be involved in the pathology of neurodegenerative diseases. Manganese (Mn), a neurotoxic metal, has the potential to induce microglia-mediated neuroinflammation as well as autophagy dysfunction. NLRP3 (NLR family, pyrin...

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Gepubliceerd in:Autophagy
Hoofdauteurs: Wang, Diya, Zhang, Jianbin, Jiang, Wenkai, Cao, Zipeng, Zhao, Fang, Cai, Tongjian, Aschner, Michael, Luo, Wenjing
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2017
Onderwerpen:
Basic Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446056/
https://ncbi.nlm.nih.gov/pubmed/28318352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1293766
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