Krüppel-like transcription factor KLF10 suppresses TGFβ-induced epithelial-to-mesenchymal transition via a negative feedback mechanism

TGFβ-SMAD signaling exerts a contextual effect that suppresses malignant growth early in epithelial tumorigenesis but promotes metastasis at later stages. Longstanding challenges in resolving this functional dichotomy may uncover new strategies to treat advanced carcinomas. The Krüppel-like transcri...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Mishra, Vivek Kumar, Subramaniam, Malayannan, Kari, Vijayalakshmi, Pitel, Kevin S., Baumgart, Simon J., Naylor, Ryan M., Nagarajan, Sankari, Wegwitz, Florian, Ellenrieder, Volker, Hawse, John R., Johnsen, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445903/
https://ncbi.nlm.nih.gov/pubmed/28249899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2589
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