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Epidithiodiketopiperazines: Strain-Promoted Thiol-Mediated Cellular Uptake at the Highest Tension
[Image: see text] The disulfide dihedral angle in epidithiodiketopiperazines (ETPs) is near 0°. Application of this highest possible ring tension to strain-promoted thiol-mediated uptake results in efficient delivery to the cytosol and nucleus. Compared to the previous best asparagusic acid (AspA),...
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| 出版年: | ACS Cent Sci |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical Society
2017
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5445525/ https://ncbi.nlm.nih.gov/pubmed/28573207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.7b00080 |
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