Melatonin-mediated mitophagy protects against early brain injury after subarachnoid hemorrhage through inhibition of NLRP3 inflammasome activation

The NLRP3 inflammasome is activated in the early period following subarachnoid hemorrhage(SAH), resulting in inflammatory responses. Recent studies have shown that activation of NLRP3 inflammasome is suppressed by autophagy, but the potential mechanism is unclear. In this study, we examined whether...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Cao, Shenglong, Shrestha, Sudeep, Li, Jianru, Yu, Xiaobo, Chen, Jingyin, Yan, Feng, Ying, Guangyu, Gu, Chi, Wang, Lin, Chen, Gao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445068/
https://ncbi.nlm.nih.gov/pubmed/28546552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02679-z
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