Simplified microsatellite instability detection protocol provides equivalent sensitivity to robust detection strategies in Lynch syndrome patients

OBJECTIVE: : Germline mutations in mismatch repair (MMR) genes cause Lynch syndrome (LS). LS is an inherited disease, and an important consequence of MMR deficiency is microsatellite instability (MSI) phenotype. MSI phenotype influences the efficacy of 5 fluorouracil (5-FU) chemotherapy. Reproducibl...

Full description

Saved in:
Bibliographic Details
Published in:Cancer Biol Med
Main Authors: Babaei, Hadi, Zeinalian, Mehrdad, Emami, Mohammad Hassan, Hashemzadeh, Mortaza, Farahani, Najmeh, Salehi, Rasoul
Format: Artigo
Language:Inglês
Published: Chinese Anti-Cancer Association 2017
Subjects:
Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444926/
https://ncbi.nlm.nih.gov/pubmed/28607805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.20892/j.issn.2095-3941.2016.0091
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items