Reduced DNA adduct formation in replicating liver cells during continuous feeding of a chemical carcinogen.

To investigate early cellular alterations in liver DNA during hepatocarcinogenesis, we have visualized replicating cells and analyzed their DNA adduct content in livers of rats continuously fed a carcinogenic level (0.02%) of 2-acetylaminofluorene for periods up to 4 weeks. One hour prior to sacrifi...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Huitfeldt, H S, Brandtzaeg, P, Poirier, M C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54448/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2198576/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.15.5955
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