Aberrant DNA methylation in human iPSCs associates with MYC binding motifs in a clone-specific manner independent of genetics

iPSCs show variable methylation patterns between lines, some of which reflect aberrant differences relative to ESCs. To examine whether this aberrant methylation results from genetic variation or non-genetic mechanisms, we generated human iPSCs from monozygotic twins to investigate how genetic backg...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Panopoulos, Athanasia D., Smith, Erin N., Arias, Angelo D., Shepard, Peter J., Hishida, Yuriko, Modesto, Veronica, Diffenderfer, Kenneth E., Conner, Clay, Biggs, William, Sandoval, Efren, D’Antonio-Chronowska, Agnieszka, Berggren, W. Travis, Belmonte, Juan Carlos Izpisua, Frazer, Kelly A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444384/
https://ncbi.nlm.nih.gov/pubmed/28388429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.03.010
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