Class I lysine deacetylases promote glucocorticoid-induced transcriptional repression through functional interaction with LSD1

Small molecule inhibitors of lysine deacetylases (KDACs) are approved for clinical use in treatment of several diseases. Nuclear receptors, such as the glucocorticoid receptor (GR) use lysine acetyltransferases (KATs or HATs) and KDACs to regulate transcription through acetylation and deacetylation...

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Библиографические подробности
Опубликовано в: :J Steroid Biochem Mol Biol
Главные авторы: Patrick, Nina M., Griggs, Chanel A., Icenogle, Ali L., Gilpatrick, Maryam M., Kadiyala, Vineela, Jaime-Frias, Rosa, Smith, Catharine L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444329/
https://ncbi.nlm.nih.gov/pubmed/27645313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2016.09.014
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